从1到3号外显子被新霉素抗性选择 cassette 的插入所删除。通过胚胎中脑的 RT-PCR 分析和原位杂交,发现纯合突变小鼠中没有转录本。Nkx6-1 的表达经原位杂交证实未受靶向事件影响。(来源:J:69975)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
1
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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