一种新霉素筛选 cassette 替换了包含活性位点残基的 3.0kb 区域。通过检测小鼠脾细胞和 LPS B 细胞blast 的活性位点标记,确定了在纯合突变鼠中蛋白质产物的功能缺失。(来源:J:53399)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
DBA/1LacJ
Targeted
插入,基因内删除
--
1
--
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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