CD1d1和CD1d2是相邻的基因座,它们以头尾相接的方式排列,允许通过插入一个新霉素选择标记 cassette,同时删除这两个基因座的4到6号外显子。RT-PCR分析显示,纯合突变小鼠所有测试组织中均未检测到转录本。通过对纯合突变动物胸腺和脾细胞的免疫荧光染色,确定了蛋白表面表达的缺失。(引用:J:39749)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S4/SvJae
Targeted
插入,基因间区删除,基因内删除
--
--
--
78

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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