将Rel同源域的19个氨基酸(635-653)序列替换成诺卡因选择标记序列。下游序列(654-710)引入了插入突变。 Western blot结果显示野生型小鼠中存在截短肽。电泳迁移速率测定显示了DNA结合活性的缺失。(来源:J:46398, J:78376)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count