从8号到13号的外显子被替换了 neoantigenic 选择性 cassette。在来自纯合突变胚胎的成纤维细胞中,通过 Western blot 分析并未检测到编码蛋白。(来源:J:71404)
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Exons 8 through 13 were replaced with a neomycin selection cassette. Encoded protein was not detected by Western blot analysis of fibroblasts isolated from homozygous mutant embryos. (J:71404)