这个基因在经由同源重组,通过在exon 2插入PGK-neo cassette后被打乱了。对全眼膜蛋白的 Western blot 检测确认了纯合突变小鼠中没有蛋白表达(来源:77333)
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The gene was disrupted by insertion of a PGK-neo cassette into exon 2 via homologous recombination. Western blot of whole eye membrane protein confirmed the absence of protein expression in homozygous mutant mice. (J:77333)