这个基因通过同源重组,将 intron 3 和 exon 4 的部分区域替换成一个 PGK-neo 载体(反向排列),导致其在纯合突变小鼠的肝脏、肾脏和脾脏中检测不到正常的 1.9kb 转录本,根据Northern blot分析结果。(来源:J:46169)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入,基因内删除
--
1
14
41

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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