在exon 10的后面插入了一个无启动子的诺卡因抗性基因,10号内含子和11号部分外显子被删除。删除的序列编码了DNA结合区和亮氨酸螺旋区域。对总脑RNA的RT-PCR分析显示,没有检测到含有3'端序列的转录本,但检测到了lacZ序列融合转录本。(来源:J:47431)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
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1
2
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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