这段基因的200bp区域,从exon1的第5位氨基酸到部分内含子1,通过同源重组被替换了neo抗药性基因座。这个基因靶向事件特异性地打乱了产物的β1亚型,而β2和β3亚型(不使用exon1)保持不变。 Western blot实验确认了纯合突变动物中β1亚型的缺失。(来源:J:31731)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入,基因内删除
--
1
2
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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