Exon 1被替换为抗氨苄青霉素耐药基因,通过同源重组。对纯合突变动物海马组织的 Western blot 检测确认了该基因表达缺失。(来源:J:76892)
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Exon 1 was replaced with a neomycin resistance gene via homologous recombination. Western blot analysis of hippocampal extracts from homozygous mutant animals verified the absence of gene expression. (J:76892)