这个基因在exon 2通过同源重组插入了一个PGK-neo-lacZ cassette,导致所有3个阅读框内都插入了终止密码子。定向载体的PGK-neo部分两侧有LoxP位点。E11.5同源纯合突变胚胎的Northern blot分析未检测到基因转录本,而RT-PCR检测到了少量疑似来自lacZ基因的突变转录本。(来源:J:70796)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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