一个新霉素选择基因替换了编码起始密码子和一个关键结合位点的exon 2。基因表达和 Western blot 检测结果显示,目标位点为null(来源:J:58150)。
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A neomycin selection gene replaced exon 2, which encodes the initiation codon and an essential binding site. Gene expression and Western blot analyses indicated that the targeted locus was null. (J:58150)