整个编码区域被替换为一个构建,包含一个连接5'端核定位信号的lacZ基因和由胸苷激酶启动子调控的诺卡因基因。内源性启动子保持不变,控制插入的lacZ基因表达。免疫组化分析未在形态异常的胚胎中检测到cyclin A2蛋白,这些被认为可能是纯合子。(来源:J:37426)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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