Exons 2和3被替换成一个lacZ-neomycin融合基因,它没有启动子但包含一个剪接接受点和一个内部翻译起始信号(IRES)。作者认为,只有前65个氨基酸会被翻译,产生一个缺失了四个WD40域以及与染色体结合的蛋白激酶域的蛋白质。(来源:J:64874)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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