在exon 5插入了一个终止密码子,并通过同源重组在exon 6插入了一个neo cassette。neo插入破坏了细胞因子受体家族内4个保守的半胱氨酸残基。基因表达缺失通过检测纯合突变动物休息时的腹腔细胞流式细胞术结果进行了验证。(来源:J:33140)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
--
12

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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