在GTI-II启动子控制下,一个新霉素抗性基因替换了编码前6个氨基酸,包括起始甲硫氨酸以及部分近端启动子的区域。北向杂交分析证实了来自纯合突变小鼠心、肝和肾组织中没有转录本。通过 Western blot 实验,对纯合突变 MEF 细胞系的蛋白质表达也确认为缺失。(来源:J:72651)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
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1
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24

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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