插入了一个PGK-neo cassette导致了exon 4的断裂,这个exon编码了一个关键的DNA结合区域。Northern blot和Western blot的结果表明,来自纯合突变小鼠中大脑组织的提取物中,转录物和蛋白质均缺失了(来源:J:42260)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count