在1号外显子的3'端和相邻的剪接供体位点,通过同源重组被替换了抗药性基因座。通过对纯合突变动物骨骼肌的Northern和Western印迹分析,证实了基因表达的缺失。此外,RT-PCR未能扩增基因的完整编码区域,以及2、3和4号外显子对应的转录片段。(来源:J:62133)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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