通过同源重组,部分exon 1和全部exon 2被IRES-BetaGal-polyA-PGK-neo cassette替换。对脑膜提取物的 Western blot 和胰腺切片的免疫组化染色未检测到蛋白质产物。出乎意料的是,突变动物中未检测到lacZ染色。(来源:J:72316)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count