ES细胞通过转染,构建中插入了LoxP位点在exon 11上游,以及一个含诺卡因-胸腺嘧啶-激酶区的floxed序列在下游。短暂表达的Cre重组酶导致选择基因的剔除,并保留了由LoxP位点标记的exon 11。exon 11编码膜IV部分,存在于所有已知的剪接变体中。(来源:J:76715)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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