一种新霉素抗性基因座替换了包含exon 1部分和intron 1部分的基因组片段。对纯合小鼠大脑组织的 Western blot 分析显示,这个等位基因没有检测到可表达的蛋白质。(来源:J:58087)
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A neomycin resistance cassette replaced a genomic fragment containing part of exon 1 and part of intron 1. Western blot analysis on brain tissue of homozygous mice demonstrated that no detectable protein was expressed from this allele. (J:58087)