一种新霉素抗性基因座替换了包含第四外显子的基因组片段,包括起始密码子。对纯合大脑匀浆的 Western blot 分析确认了编码蛋白的缺失(来源:J:70385)
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A neomycin resistance cassette replaced a genomic fragment containing exon 4, which includes the start codon. Western blot analysis of homogenates of homozygous brains confirmed the absence of encoded protein. (J:70385)