在仅在大脑中转录的、作为不同剪接体的exon 1b插入了新霉素抗性基因座。对来自纯合大脑的RNA进行Northern blot分析显示,没有包含exon 1b的转录本表达,而包含其他剪接变异的转录本表达未受影响。 Western blot分析和免疫组化实验也证实了小脑中几乎没有蛋白质存在。(来源:J:51377)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
2
10

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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