在C57BL/6囊胚中,导入了一个带有tau-lacZ-loxP-tk-neo-loxP表达座,它取代了编码外显子,并将tau-lacZ序列置于内源性调控序列的调控之下。短暂表达的Cre重组酶剔除了胸苷激酶和诺卡因序列。在杂合突变小鼠的嗅觉轴突末梢,检测到了tau-lacZ融合蛋白的表达,这些表达出现在单个胶质细胞中。(来源:J:36595)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
--
11

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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