通过体内Cre介导的重组,从Slit1tm1Matl中去除了含有的floxed neo cassette,使得内源性位点被一个包含内质网KDEL保留序列、终止密码子和IRES-tauGFP融合蛋白的 cassette打断。初始插入替换了第二段富含亮氨酸的重复序列的部分编码。使用3'反义探针对E11.5同卵突变胚胎的中脑背根神经节进行的原位杂交未检测到mRNA。(引用:J:73904)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
--
1
--
54

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部