Skp2^tm1Kin

Exons 1-4 of this gene were replaced with a PGK-neo-poly(A) cassette via homologous recombination, resulting in the loss of the translation initiation site and F-box domain. RT-PCR verified gene expression was absent in homozygous mutant animals and immunoprecipitation failed to detect full length or truncated protein product. (J:62130)