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中文
这个基因的Exon 4和部分Exon 3被通过同源重组替换为一个PGK(G)neopA cassette。在第78位位置设计了一个终止密码子，以进一步确认无功能性等位基因。PCR和Southern blot结果显示了目标突变的存在，而Western blot分析则证实了在纯合突变动物的胸腺细胞中没有Itk蛋白。(来源：J:31230)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
