这个基因的exons 2和5被通过同源重组替换为了新抗性基因。Southern blot证实了在TC-1 ES细胞中构建的有效靶向。对胸腺细胞、淋巴结和脾脏匀浆的Western blot结果显示,纯合突变动物中没有蛋白产物(来源:J:74719)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入,基因内删除
--
1
2
13

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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