基因的启动子和第一个外显子周围插入了loxP位点,同时在第一个内含子中插入了带有frt标签的诺卡因抗性元件。对来自纯合胚胎的RNA进行RT-PCR分析显示,这个等位基因产生了异常的neo融合转录本,且正常mRNA水平有所降低。(来源:J:74631)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6NCrlj x CBA/JNCrlj)F1
Targeted
插入
--
1
10
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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