一个新霉素抗性基因座替换了exon 2以及其附近的内含子序列。对来自纯合胚胎的RNA进行RT-PCR分析显示,这个等位基因未产生可检测到的转录本,而对肝脏匀浆的 Western blot 检测也证实了该等位基因未表达蛋白质。(来源:J:65092)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
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1
1
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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