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中文
通过敲入策略，将719位的酪氨酸替换成苯丙氨酸（Y719F），这个突变是为了阻止SH2域蛋白，包括PI3-激酶p85亚基的结合，并阻断后续信号传导。新霉素的保留导致kit表达减少了75%（来源：J:61141）。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
