一种新霉素筛选 cassette 替换了包含 exons 7-11 的基因组 DNA 片段,这些编码区域涉及一个 kringle 区域、激活切割位点以及活性位点的部分。对来自纯合小鼠肝脏提取物的 Western blot 分析显示,这个等位基因没有检测到可识别的蛋白表达。(来源:J:48274)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
6
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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