在转基因中,一个新霉素选择座替换了前导序列的200bp,包括编码信号肽的序列。来自纯合小鼠睾丸和大脑的RNA进行Northern blot分析后,未检测到从这个等位基因产生的转录本。对纯合小鼠睾丸和子宫提取物进行的Western blot分析也证实了这个等位基因未表达出可检测到的蛋白质。(来源:J:46376)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S2/SvPas
Targeted
插入,基因内删除
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1
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26

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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