在exon 1的5'端插入了一个loxP位点,然后在exon 1的3'端插入了含诺卡因和胸腺嘧啶激酶选择标记的loxP-flanked序列。在将选择标记元件通过短暂的Cre表达从胚胎干细胞中去除后,最终产生了杂合小鼠,exon 1的3'端保留了一个loxP位点。(来源:J:72241)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Targeted
插入
--
1
1
44

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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