这个等位基因是由Nf1tm1Par衍生而来的。第31和32个外显子通过Cre介导的重组被删除了。这是通过将携带NF1tm1Par突变的鼠与携带Egr2tm2(Cre)Pch(129S2/SvPas品系)的鼠交配实现的。这个删除是可遗传的,会通过遗传方式传递给后代。(来源:J:68558)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
基因内删除
--
1
24
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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