在仅有的编码exon5'端插入了一个loxP位点,然后在exon的3'末端插入了loxP引导的hygromycin抗性基因簇。通过短暂的Cre表达,将hygromycin选择性基因簇从ES细胞中去除,使得在产生嵌合小鼠前,前有一个loxP位点。(来源:J:71969)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入
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1
2
101

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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