在第5外显子中插入了终止密码子、GFP基因和一个由loxP序列标记的诺卡因选择性载体。免疫印迹分析显示,纯合小鼠组织中编码蛋白完全阴性,而纯合小鼠肾组织的免疫组化检测也未检测到该蛋白。(来源:J:61946)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
插入
--
1
1
14

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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