一种新霉素筛选 cassette 替换了包含 exons 5 和 6 的基因片段,这些 exons 包含编码酪氨酸磷酸酶活性位点的序列。对来自纯合小鼠的肝微粒体进行 Western blot 分析证实,这个等位基因不表达可检测到的蛋白质。(来源:J:53437)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入,基因内删除
--
1
1
32

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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