一个新霉素抗性基因座替换了包含编码蛋白激酶活性必需的三肽双磷酸化模体(211-267位氨基酸序列)的基因组片段。对来自纯合小鼠的总脑RNA进行Northern blot和RT-PCR分析未检测到任何转录本。对纯合小鼠海马体提取物进行的酶活性测定确认了这个等位基因上未表达出功能蛋白。(来源:J:43658)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
1
41

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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