将一个含荧光素酶抗性基因的插入,位于第二外显子,导致了开放阅读框中的提前终止密码子。在携带Hoxb8tm1Mrc突变的受精卵中,通过pronuclear注射pMC1-Cre,去除了neo cassette,第二外显子留下一个loxP位点。对大脑的RT-PCR研究显示,这个突变等位基因产生了比野生型更长的转录本。(来源:J:73745)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
基因内删除
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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