在PGK-neomycin抗性 cassette中,第20号外显子被替换,同时19号和21号外显子各被去掉了半个,19号外显子还引入了一个在阅读框内的终止密码子。RNA酶保护分析显示,野生型小鼠大脑和肾脏中有保护片段,而纯合突变雄性小鼠中则无此片段。(来源:J:47884)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S/SvEv-Gpi1c
Targeted
插入,基因内删除
--
1
2
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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