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在exon 2的两侧插入了LoxP位点。接着，3'于LoxP位点插入了诺卡因选择标记和胸苷激酶基因，这些通过转暂时性Cre重组酶在ES细胞中被移除，然后用于构建嵌合小鼠。在纯合小鼠中进行的 Western blot 和免疫组化分析显示编码蛋白的表达未见明显变化。(来源：J:71092)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
