同源重组在编码236-258氨基酸的外显子下游插入了含诺卡因-胸苷激酶表达座的floxed序列,该序列位于内腔"茎"区域,同时在该外显子上游增加了一个loxP位点。在ES细胞中,通过Cre介导的重组剔除了neo-tk序列,使得外显子两侧留下了loxP序列标记。(来源:J:41621)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count