一段包含编码区域三分之二的基因组片段被替换成含有诺卡因选择标记的neo cassette,这个neo cassette由loxP序列 flank。最终等位基因通过Cre介导的重组被去除了。对纯合小鼠睾丸RNA的Northern blot分析显示,这个等位基因没有产生可检测到的转录本,而Western blot分析证实,纯合小鼠的脑、睾丸和胰腺中也未检测到任何可识别的蛋白质。(来源:J:50338)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入,基因内删除
--
1
1
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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