同源重组在内含子2中引入了floxed neo抗药性基因座,而在内含子1中则有一个loxP位点。在CMV启动子驱动的体内Cre重组活动中,这种基因座在生殖细胞中被剔除,留下exon 2两侧各有一个loxP位点,编码受体结合域中大约三分之一的外显子部分。(来源:J:75074, J:97780)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1+
Targeted
插入,基因内删除
--
1
6
181

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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