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A PGK-neomycin resistance cassette replaced ~11.5kb of sequence, including the promoter and associated regulatory sequences. RT-PCR analysis of liver did not detect wild-type transcript in homozygous mutant mice. Immunoprecipitation and kinase assays of liver and spleen did not detect LYN autokinase activity in homozygous mutant mice. (J:29356)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
