一种诺美西林筛选 cassette 替换了 intron 12 的部分以及特异性 exon 的部分。这些序列包含了特异性启动子和转录起始点。体细胞型蛋白的表达也被干扰了。蛋白活性检测证实了纯合小鼠在血清、肺、肾和睾丸中均无功能蛋白产生。(来源:J:33018)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
4
15

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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