AKR/J、CAST/Ei和129P2/OlaHsd这些基因型能保护 tubby 小鼠免受听力损失,而C57BL/6基因型则使tubby小鼠对听力损失敏感。在易感和抗病品系中,Mtap1a基因存在大量序列变异。通过转基因拯救实验,确认了Mtap1a是导致moth1表型的基因(J:75815)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
QTL
不适用
隐性
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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