在IIIb外显子的两侧插入了LoxP位点:在IIIb外显子的3'内含子和5'内含子中分别插入了loxP介导的诺卡因抗性 cassette,然后通过转染含Cre重组酶表达载体,获得了定向的ES细胞系。筛选出保留IIIb和LoxP座的细胞株,用于囊胚的注射。(来源:J:59285)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
19
13

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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