Fgfr1^tm2.1Cxd

Derivative of Fgfr1tm2Cxd. A point mutation was introduced into exon 7 that altered codon 250 from one encoding proline to one encoding arginine (P250R). This mutation corresponds to a known human mutation in this gene that is a cause of Pfeiffer syndrome. A loxP flanked neomycin cassette in intron 6 was removed via Cre mediated recombination leaving one loxP site. (J:63959)